The Next Challenge to Understanding Multiple Sclerosis

admin — Wed, 23 Sep 2009 11:54:59 +0000

Introduction

As we know Multiple sclerosis is a common neurological disease that affects 1 in 1,000 people, most commonly young women, although men too to a lesser extent. The typical disease progress includes attacks and remissions with slowly progressing disability. Current therapies can prevent the appearance of new events, but they have much less effect on disease progression and serve mainly to moderate the initial relapsing-remitting phase.

May 15th 2009 saw a new review published from Oxford University by Lars Fugger, Manuel A. Friese and John I. Bell. In it they describe the current and new approaches that can be applied to define the functional role of the known genes involved in multiple sclerosis but also point out that environmental factors have a bearing on the function of the genes.

Environmental factors

Unfortunately, these environmental factors have proved to be even more elusive than the genes. Why do different areas of the world have a different prevalence and incidence of MS ? Could this be climate? Diet ? Genetics ? Lifestyle ? Infections ? What could these infections be ? Numerous viral and bacterial infections are potential candidates such as those found in the respiratory airways and gastrointestinal or urinary tracts as they are often associated with relapses, but no single infection has been consistently associated with disease.

We do not know how so many different infections could have a role in MS and how they might interact with genetic risk factors but, it is also important to try to understand how non-infectious risk factors, such as sunlight, may interact with genetic risk factors.

Asking the questions

The biggest challenge will be to use genetic information to ask questions about the environmental factors that interact with gene pathways and contribute to disease development. The identification of the exact disease susceptibility gene does not necessarily define the pathway involved in disease development.

The insights gained from functional studies may help the study of environmental risk factors by using methodology that goes well beyond the conventional approaches of population epidemiology. The improving capacity for modelling and simulation using genetic data may lead to the identification of the additional environmental factors that interact with genetic factors to cause disease.

Tags:climate,course of MS,Environmental,gene,genetic risk factors,Lifestyle,ms diagnosis,sunlight,susceptibility gene

In pursuit of a happiness gene

admin — Wed, 24 Jun 2009 13:19:52 +0000

Wed, 06/24/2009 – 04:11 – NLN

The pursuit of happiness characterizes the human condition. But for those suffering from stress, money trouble or chronic illness, a positive outlook on life can be difficult to find. Now, a Tel Aviv University researcher says we should look to our genes.

Prof. Yoram Barak of Tel Aviv University’s Sackler School of Medicine is engaged in the “attempt to find the happiness gene, the genetic component of happiness,” which may be 50% responsible for an optimistic outlook. The research is a collaboration between Tel Aviv University and its affiliated research hospital, the Chaim Sheba Medical Centre at Tel Hashomer, which is the largest hospital in Israel.

Initial research findings have made Prof. Barak optimistic about their ability to succeed. “If something is genetic, it should have a large concordance among twins,” he says. “And the twin studies we are looking at show that 50% of happiness is genetically determined.” Prof. Barak is now working with Prof. Anat Achiron of the Sheba Medical Center to identify the specific genes that are associated with happiness.

Dr. Barak’s current findings in the hunt for the happiness gene were presented at The World Congress on Treatment and Research in Multiple Sclerosis in Montreal, Canada in 2008, and most recently detailed in the journal Expert Review of Neurotherapeutics, April 2009.

We may be a long way off from being able to genetically engineer happiness, Prof. Barak says, but we can start by thinking positively. Much of his work is based on positive psychology, which is the “fastest and largest growing area of psychology in the United States ― and in the world,” he says.

For the 50% of happiness that is not genetic, Prof. Barak is working on a program of positive psychology workshops, with exercises he recently tested in a one-day workshop for 120 participants at the Multiple Sclerosis Society of Israel. Early results indicate that the workshops improved the happiness level of participants by as much as 30%.

This work is dedicated to finding “practical and intervention oriented research and the application of psychology into medicine,” says Prof. Barak. His research into the physical affects of mental state on patients with neurological diseases is an attempt to bridge the gap between psychology and clinical medicine.

Feeling good in mind and body

Prof. Barak says that the psychological benefits of the program were accompanied by physical benefits as well. “We were able to raise levels of happiness in these patients so they were just about equal to those of healthy subjects,” he says. “If we can apply positive psychology, we can better their adherence to their treatment regime. And we have been able to show that there is a stabilization of the neurological disability as well.”

For healthy individuals, Prof. Barak says that his happiness exercises can enrich their lives, too. Meanwhile, his search for the happiness gene goes on.

American Friends of Tel Aviv University

Tags:Dr. Barak,gene,happiness,Prof. Barak,psychology,research

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